Circulating type-1 anti-tumor CD4+ T cells are preferentially pro-apoptotic in cancer patients

Melanoma patients frequently exhibit a deficiency in Type-1 (but not Type-2 or regulatory) CD4+ T cell responses against tumor-associated antigens (TAA), which may limit protection against cancer progression or responsiveness to immunotherapy in these individuals. Since such deficiency was acutely e...

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Bibliografiset tiedot
Päätekijät: Amy K. Wesa, Maja eMandic, Jennifer L. Taylor, Stergios eMoschos, John M. Kirkwood, William W. Kwok, James Harold Finke, Walter J. Storkus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2014-09-01
Sarja:Frontiers in Oncology
Aiheet:
Apoptosis
CD4+ T cells
tumor
Peripheral Blood
Type-1
Linkit:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00266/full
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