Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency

Mitochondrial disorders cause energy failure and metabolic derangements. Metabolome profiling in patients and animal models may identify affected metabolic pathways and reveal new biomarkers of disease progression. Using liver metabolomics we have shown a starvation-like condition in a knock-in (Bcs...

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Detalhes bibliográficos
Main Authors: Jayasimman Rajendran, Nikica Tomašić, Heike Kotarsky, Eva Hansson, Vidya Velagapudi, Jukka Kallijärvi, Vineta Fellman
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-11-01
Colecção:International Journal of Molecular Sciences
Assuntos:
mitochondrial disorder
BCS1L
mouse model
metabolite
dextrose diet
nutrition
GRACILE syndrome
Acesso em linha:http://www.mdpi.com/1422-0067/17/11/1824
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