A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice.

Traditionally, immunology has considered a meaningful antibody response to be marked by large amounts of high-affinity antibodies reactive with the specific inciting antigen; the detection of small amounts of low-affinity antibodies binding to seemingly unrelated antigens has been considered to be b...

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Main Authors: Yifat Merbl, Royi Itzchak, Tal Vider-Shalit, Yoram Louzoun, Francisco J Quintana, Ezra Vadai, Lea Eisenbach, Irun R Cohen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2009-06-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2699142?pdf=render
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