Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in vivo systems are required to rapidly evaluate therape...

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Main Authors: Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2019-08-01
Serier:Disease Models & Mechanisms
Fag:
Crohn's disease
DSS injury model
Epithelial barrier
IBD
Lysosome-rich enterocytes
Online adgang:http://dmm.biologists.org/content/12/8/dmm037432
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