Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.

Tuberculosis is a current major world-health problem, exacerbated by the causative pathogen, Mycobacterium tuberculosis (Mtb), becoming increasingly resistant to conventional antibiotic treatment. Mtb is able to counteract the bactericidal mechanisms of leukocytes to survive intracellularly and deve...

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Bibliographic Details
Main Authors: Philip M Elks, Sabrina Brizee, Michiel van der Vaart, Sarah R Walmsley, Fredericus J van Eeden, Stephen A Renshaw, Annemarie H Meijer
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3868520?pdf=render
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