Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of Cardiac Hypertrophy

Background/Aims: Adult cardiomyocytes can re-enter cell cycle as stimulated by prohypertrophic factors although they withdraw from cell cycle soon after birth. p21WAF1/CIP1, a cyclin-dependent kinase inhibitor, has been implicated in cardiac hypertrophy, however, its precise contribution to this pro...

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Main Authors: Yang-Fei Tong, Yan Wang, Yuan-Yuan Ding, Jing-Mei Li, Xi-Chun Pan, Xiao-Lan Lu, Xiao-Hong Chen, Ya Liu, Hai-Gang Zhang
Format: Artigo
Jezik:Inglês
Izdano: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Serija:Cellular Physiology and Biochemistry
Teme:
Cardiac hypertrophy
Cell cycle
Cyclin-dependent kinase inhibitor 1a
p21WAF1/CIP
Online dostop:http://www.karger.com/Article/FullText/479407
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