Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract

Abstract Zika virus (ZIKV) can cause devastating effects in the unborn fetus of pregnant women. To develop a candidate vaccine that can protect human fetuses, we generated a panel of live measles vaccine (MV) vectors expressing ZIKV-E and -NS1. Our MV-based ZIKV-E vaccine, MV-E2, protected mice from...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Drishya Kurup, Christoph Wirblich, Rachael Lambert, Leila Zabihi Diba, Benjamin E. Leiby, Matthias J. Schnell
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2022-04-01
Cyfres:npj Vaccines
Mynediad Ar-lein:https://doi.org/10.1038/s41541-022-00464-2
Tagiau: Ychwanegu Tag
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