A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples

Abstract Background Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early detection of colorectal cancer and premalignant advanced adenomas, t...

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Main Authors: María Gallardo-Gómez, Sebastian Moran, María Páez de la Cadena, Vicenta Soledad Martínez-Zorzano, Francisco Javier Rodríguez-Berrocal, Mar Rodríguez-Girondo, Manel Esteller, Joaquín Cubiella, Luis Bujanda, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Loretta De Chiara
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2018-04-01
Series:Clinical Epigenetics
Assuntos:
Advanced adenomas
Circulating cell-free DNA
Colorectal cancer
DNA methylation
MethylationEPIC
Non-invasive diagnostic biomarkers
Acceso en liña:http://link.springer.com/article/10.1186/s13148-018-0487-y
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