OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma

Abstract Background Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despite extensive research, no significant therapeutic advancements have bee...

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Main Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso, Rheal A. Towner
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2020-11-01
Sraith:Journal of Translational Medicine
Ábhair:
Diffuse intrinsic pontine glioma (DIPG)
ACVR1 mutation
Patient-derived xenograft (PDX)
OKN-007
Magnetic resonance imaging (MRI)
Diffusion-weighted imaging (DWI)
Rochtain Ar Líne:http://link.springer.com/article/10.1186/s12967-020-02593-5
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