Disturbed T cell signaling and altered Th17 and regulatory T cell subsets in the pathogenesis of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies against nuclear components. Circulating immune complexes of chromatin and autoantibodies deposit in various tissues leading to inflammation and tissue damage. It has been well documented that...

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Bibliographic Details
Main Authors: Nils eRother, Johan eVan Der Vlag
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Th17 Cells
T cells
Tregs
systemic lupus erythematosus
TCR-signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00610/full
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