Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure

AimClinical utility of doxorubicin (DOX) is limited by its cardiotoxic side effect, and the underlying mechanism still needs to be fully elucidated. This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF) and its underlying mechanism.Main MethodsSprague...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xiao-yi Du, Dao-chun Xiang, Ping Gao, Hua Peng, Ya-li Liu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2022-04-01
Cyfres:Frontiers in Oncology
Pynciau:
doxorubicin
cardiotoxicity
heart failure
(Pro) renin receptor
RAC1
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fonc.2022.874852/full
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