Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure

AimClinical utility of doxorubicin (DOX) is limited by its cardiotoxic side effect, and the underlying mechanism still needs to be fully elucidated. This research aimed to examine the role of (pro)renin receptor (PRR) in DOX-induced heart failure (HF) and its underlying mechanism.Main MethodsSprague...

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Bibliographic Details
Main Authors: Xiao-yi Du, Dao-chun Xiang, Ping Gao, Hua Peng, Ya-li Liu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
doxorubicin
cardiotoxicity
heart failure
(Pro) renin receptor
RAC1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.874852/full
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