Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-, and trimethylase of polycomb-repressive complex 2. Ezh2 has a context-dependent role in different cancers as an oncogene or tumor suppressor a...

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Main Authors: BaoHan T. Vo, Chunliang Li, Marc A. Morgan, Ilan Theurillat, David Finkelstein, Shaela Wright, Judith Hyle, Stephanie M.C. Smith, Yiping Fan, Yong-Dong Wang, Gang Wu, Brent A. Orr, Paul A. Northcott, Ali Shilatifard, Charles J. Sherr, Martine F. Roussel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-03-01
Colecção:Cell Reports
Assuntos:
group 3 medulloblastoma
MYC
polycomb-repressive complex 2
PRC2
enhancer of zeste homology 2
EZH2
suppressor of zeste 12 homolog
SUZ12
growth factor independent 1
GFI1
histone H3 modification
Hox genes
epigenetic repression
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124717302917
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