End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression

Background: The molecular mechanisms underlying chronic kidney disease (CKD) transition to end-stage renal disease (ESRD) and CKD acceleration of cardiovascular and other tissue inflammations remain poorly determined. Methods: We conducted a comprehensive data analyses on 7 microarray datasets in pe...

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Main Authors: Ruijing Zhang, Jason Saredy, Ying Shao, Tian Yao, Lu Liu, Fatma Saaoud, William Y. Yang, Yu Sun, Candice Johnson, Charles Drummer, IV, Hangfei Fu, Yifan Lu, Keman Xu, Ming Liu, Jirong Wang, Elizabeth Cutler, Daohai Yu, Xiaohua Jiang, Yafeng Li, Rongshan Li, Lihua Wang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-07-01
Colecção:Redox Biology
Assuntos:
Chronic kidney disease
(CKD)
End-stage renal disease
(ESRD)
PBMC secretome
Reactive oxygen species
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231719315502
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