Nobiletin, a Polymethoxy Flavonoid, Protects Against Cardiac Hypertrophy Induced by Pressure-Overload via Inhibition of NAPDH Oxidases and Endoplasmic Reticulum Stress

Background/Aims: An increase in oxidative stress has been implicated in the pathophysiology of pressure-overload induced cardiac hypertrophy. Nobiletin (NOB), extracted from the fruit peel of citrus, possesses anti-oxidative property. Our study aimed to investigate the protective role of NOB in the...

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Main Authors: Ning Zhang, Wen-Ying Wei, Zheng Yang, Yan Che, Ya-Ge Jin, Hai-Han Liao, Sha-sha Wang, Wei Deng, Qi-Zhu Tang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Colecção:Cellular Physiology and Biochemistry
Assuntos:
Nobiletin
Cardiac hypertrophy
NAPDH oxidase
Endoplasmic reticulum stress
Acesso em linha:http://www.karger.com/Article/FullText/478960
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