Intranasal bovine β-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine

Respiratory mucosal immunization is an effective immunization strategy against tuberculosis (TB), and effective mucosal vaccines require adjuvants which can promote protective immunity without deleterious inflammation. Mucosal BCG (Bacille Calmette-Guerin) is effective, but it causes severe inflamma...

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Detalhes bibliográficos
Main Authors: Zhengmin Liang, Hao Li, Mengjin Qu, Yiduo Liu, Yuanzhi Wang, Haoran Wang, Yuhui Dong, Yulan Chen, Xin Ge, Xiangmei Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2022-05-01
Colecção:Virulence
Assuntos:
Tuberculosis
Bovine β-defensin-5
Mucosal immunization
TRM
Antibody response
Acesso em linha:https://www.tandfonline.com/doi/10.1080/21505594.2022.2080342
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