Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular mechanisms connecting APOE4 to AD are not well und...

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Main Authors: Stella A. Belonwu, Yaqiao Li, Daniel G. Bunis, Arjun Arkal Rao, Caroline Warly Solsberg, Tomiko Oskotsky, Alice L. Taubes, Brian Grone, Kelly A. Zalocusky, Gabriela K. Fragiadakis, Yadong Huang, Marina Sirota
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Aging Neuroscience
Assuntos:
Alzheimer’s disease
APOE
single-cell
RNA-sequencing
differential expression
network enrichment
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnagi.2022.749991/full
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