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Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest.

Neural crest cells are multipotent progenitor cells that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as smooth muscle. The mechanisms controlling this cell fate choice are not known. The basic Helix-loop-Helix (bHLH) transcription factor Twist1 is expres...

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Detalhes bibliográficos
Main Authors: Joshua W Vincentz, Beth A Firulli, Andrea Lin, Douglas B Spicer, Marthe J Howard, Anthony B Firulli
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2013-03-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC3605159?pdf=render
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