TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway

Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, the biological role of CLDN4 in GBM is still unknown. This study aimed to determine whether CLDN4 mediat...

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Hauptverfasser: Tengfeng Yan, Yinqiu Tan, Gang Deng, Zhiqiang Sun, Baohui Liu, Yixuan Wang, Fanen Yuan, Qian Sun, Ping Hu, Lun Gao, Daofeng Tian, Qianxue Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2022-04-01
Schriftenreihe:Cell Death and Disease
Online Zugang:https://doi.org/10.1038/s41419-022-04788-8
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