Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment.

BACKGROUND: The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2'-deoxycytidine (DAC) demethylation therapy...

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Main Authors: Ramin Radpour, Zeinab Barekati, Corina Kohler, Martin M Schumacher, Thomas Grussenmeyer, Paul Jenoe, Nicole Hartmann, Suzette Moes, Martin Letzkus, Johannes Bitzer, Ivan Lefkovits, Frank Staedtler, Xiao Yan Zhong
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2011-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3208622?pdf=render
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