Integrated Epigenetics of Human Breast Cancer: Synoptic Investigation of Targeted Genes, MicroRNAs and Proteins upon Demethylation Treatment

BACKGROUND: The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2′-deoxycytidine (DAC) demethylation therapy in b...

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Detalhes bibliográficos
Main Authors: Radpour, Ramin, Barekati, Zeinab, Kohler, Corina, Schumacher, Martin M., Grussenmeyer, Thomas, Jenoe, Paul, Hartmann, Nicole, Moes, Suzette, Letzkus, Martin, Bitzer, Johannes, Lefkovits, Ivan, Staedtler, Frank, Zhong, Xiao Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208622/
https://ncbi.nlm.nih.gov/pubmed/22076154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027355
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