Analgesic action of hexaazaisowurtzitane derivative in somatic pain models caused by TRPA1 and TRPV1 Ion channels activation

The aim of this study was to assess the analgesic action of thiowurtzine in somatogenic nociception models by activation of TRPA1 and TRPV1 ion channels.Materials and methods. The object of the study is the compound 4-(3,4-dibromothiophenecarbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracycl...

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Main Authors: S. G. Krylova, K. A. Lopatina, E. P. Zueva, E. A. Safonova, T. N. Povet’eva, Yu. V. Nesterova, O. G. Afanas’eva, P. V. Kul’pin, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov
Formato: Artigo
Idioma:Inglês
Publicado em: Siberian State Medical University (Tomsk) 2021-01-01
Colecção:Bûlleten' Sibirskoj Mediciny
Assuntos:
hexaazaisowurtzitane
thiowurtzine
analgesic activity
somatogenic nociception
trp ion channels
formalin test
capsaicin
ketorolac
diclofenac
anti-inflammatory activity
Acesso em linha:https://bulletin.tomsk.ru/jour/article/view/4158
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