The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?†

The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and proliferation. The canonical AMP-dependent mechanism of a...

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Auteurs principaux: Diana Vara-Ciruelos, Fiona M. Russell, D. Grahame Hardie
Format: Artigo
Langue:Inglês
Publié: The Royal Society 2019-07-01
Collection:Open Biology
Sujets:
ampk
cancer
lkb1
metabolism
tumour suppressors
tumour promoters
Accès en ligne:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190099
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