Anti-EphA2 Antibodies Decrease EphA2 Protein Levels in Murine CT26 Colorectal and Human MDA-231 Breast Tumors But Do Not Inhibit Tumor Growth

The EphA2 receptor tyrosine kinase has been shown to be over-expressed in cancer and a monoclonal antibody (mAb) that activates and down-modulates EphA2 was reported to inhibit the growth of human breast and lung tumor xenografts in nude mice. Reduction of EphA2 levels by treatment with anti-EphA2 s...

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Bibliographic Details
Main Authors: David Kiewlich, Jianhuan Zhang, Cynthia Gross, Wei Xia, Brent Larsen, Ronald R. Cobb, Sandra Biroc, Jian-Ming Gu, Takashi Sato, David R. Light, Tara Heitner, Joerg Willuda, David Vogel, Felipe Monteclaro, Andrzej Citkowicz, Steve R. Roffler, Deborah A. Zajchowski
Format: Artigo
Language:Inglês
Published: Elsevier 2006-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
EphA2
ephrinAl
antibodies
colorectal cancer
breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800370
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