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Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis

Abstract Cholangiocarcinoma (CCA) is a subtype of bile duct cancer usually diagnosed late with a low survival rate and no satisfactorily systemic treatment. Recently, regorafenib has been accepted as a second-line treatment for CCA patients. In this study, we investigated the potential signal transd...

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Detalhes bibliográficos
Main Authors: Yu-Chan Chang, Chien-Hsiu Li, Ming-Hsien Chan, Ming-Huang Chen, Chun-Nan Yeh, Michael Hsiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2022-04-01
Colecção:Cell Death and Disease
Acesso em linha:https://doi.org/10.1038/s41419-022-04816-7
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