Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling

Reactive oxygen species (ROS) is major risk factor in neuronal diseases including ischemia. Although biliverdin reductase A (BLVRA) plays a pivotal role in cell survival via its antioxidant function, its role in hippocampal neuronal (HT-22) cells and animal ischemic injury is not clearly understood...

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Main Authors: Sang Jin Kim, Min Jea Shin, Dae Won Kim, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Eun Jeong Sohn, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Yong-Jun Cho, Duk-Soo Kim, Won Sik Eum, Soo Young Choi
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Assuntos:
Tat-BLVRA
oxidative stress
MAPK
ischemic injury
protein therapy
Acceso en liña:https://www.mdpi.com/1422-0067/21/8/2672
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