Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

Oxidative stress would play a role in the pathophysiology of sickle cell anemia (SCA). We tested the impact of common SCA genetic modifiers (alpha-thalassemia, G6PD deficiency, HbF quantitative trait loci; QTL) and pro/antioxidant genes polymorphisms (<i>SOD2</i> rs4880, <i>XO</...

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Main Authors: Fatou Gueye Tall, Cyril Martin, El hadji Malick Ndour, Camille Faes, Indou Déme Ly, Vincent Pialoux, Philippe Connes, Papa Madieye Gueye, Rokhaya Ndiaye Diallo, Céline Renoux, Ibrahima Diagne, Pape Amadou Diop, Aynina Cissé, Philomène Lopez Sall, Philippe Joly
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-09-01
Series:Antioxidants
Assuntos:
sickle cell anemia
hydroxyurea-free
alpha-thalassemia
HbF QTL
G6PD deficiency
clinical severity
Acceso en liña:https://www.mdpi.com/2076-3921/9/9/863
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