Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

Oxidative stress would play a role in the pathophysiology of sickle cell anemia (SCA). We tested the impact of common SCA genetic modifiers (alpha-thalassemia, G6PD deficiency, HbF quantitative trait loci; QTL) and pro/antioxidant genes polymorphisms (<i>SOD2</i> rs4880, <i>XO</...

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Hauptverfasser: Fatou Gueye Tall, Cyril Martin, El hadji Malick Ndour, Camille Faes, Indou Déme Ly, Vincent Pialoux, Philippe Connes, Papa Madieye Gueye, Rokhaya Ndiaye Diallo, Céline Renoux, Ibrahima Diagne, Pape Amadou Diop, Aynina Cissé, Philomène Lopez Sall, Philippe Joly
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-09-01
Schriftenreihe:Antioxidants
Schlagworte:
sickle cell anemia
hydroxyurea-free
alpha-thalassemia
HbF QTL
G6PD deficiency
clinical severity
Online Zugang:https://www.mdpi.com/2076-3921/9/9/863
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