Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease.

Caffeine has been considered a neuroprotective agent against Parkinson's disease (PD). Recent metabolomic analysis showed that levels of caffeine and its metabolites were decreased in sera from patients with PD compared with those from healthy controls. We focused on theophylline, which is one...

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Библиографические подробности
Главные авторы: Takuma Ohmichi, Takashi Kasai, Tadashi Kosaka, Keisuke Shikata, Harutsugu Tatebe, Ryotaro Ishii, Makiko Shinomoto, Toshiki Mizuno, Takahiko Tokuda
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2018-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC6059449?pdf=render
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