p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion

Summary: We report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects in mammary gland branching. Ectopic progesterone in p73-def...

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Главные авторы: Gabriela L. Santos Guasch, J Scott Beeler, Clayton B. Marshall, Timothy M. Shaver, Quanhu Sheng, Kimberly N. Johnson, Kelli L. Boyd, Bryan J. Venters, Rebecca S. Cook, Jennifer A. Pietenpol
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2018-10-01
Серии:iScience
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2589004218301536
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