p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion

We report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects in mammary gland branching. Ectopic progesterone in p73-deficient mi...

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Veröffentlicht in:iScience
Hauptverfasser: Santos Guasch, Gabriela L., Beeler, J Scott, Marshall, Clayton B., Shaver, Timothy M., Sheng, Quanhu, Johnson, Kimberly N., Boyd, Kelli L., Venters, Bryan J., Cook, Rebecca S., Pietenpol, Jennifer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197761/
https://ncbi.nlm.nih.gov/pubmed/30340069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.09.018
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