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Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs

Efforts to take advantage of the beneficial activities of thyrotropin-releasing hormone (TRH) in the brain are hampered by its poor metabolic stability and lack of adequate central nervous system bioavailability. We report here novel and metabolically stable analogs that we derived from TRH by repla...

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Библиографические подробности
Главные авторы: Laszlo Prokai, Krisztina Konya, Szabolcs Szarka, Katalin Prokai-Tatrai, Vien Nguyen
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2013-05-01
Серии:Pharmaceutics
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Online-ссылка:http://www.mdpi.com/1999-4923/5/2/318
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