Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs

Efforts to take advantage of the beneficial activities of thyrotropin-releasing hormone (TRH) in the brain are hampered by its poor metabolic stability and lack of adequate central nervous system bioavailability. We report here novel and metabolically stable analogs that we derived from TRH by repla...

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Autori principali: Laszlo Prokai, Krisztina Konya, Szabolcs Szarka, Katalin Prokai-Tatrai, Vien Nguyen
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2013-05-01
Serie:Pharmaceutics
Soggetti:
bioprecursor prodrug
brain-targeting delivery
thyrotropin-releasing hormone
synthetic peptide analog
analeptic effect
antidepressant-like activity
Accesso online:http://www.mdpi.com/1999-4923/5/2/318
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