Design and Synthesis of Matrine Derivatives as Novel Anti-Pulmonary Fibrotic Agents via Repression of the TGFβ/Smad Pathway

A total of 18 matrine derivatives were designed, synthesized, and evaluated for their inhibitory effect against TGF-&#946;1-induced total collagen accumulation in human fetal lung fibroblast MRC-5 cell lines. Among them, compound <b>3f</b> displayed the most potent anti-fibrotic acti...

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Main Authors: Lingyu Li, Liyan Ma, Dongchun Wang, Hongmei Jia, Meng Yu, Yucheng Gu, Hai Shang, Zhongmei Zou
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-03-01
Colecção:Molecules
Assuntos:
idiopathic pulmonary fibrosis
matrine
indole
structure activity relationship
fibroblast-to-myofibroblast transition
TGF-β/Smad pathway
Acesso em linha:https://www.mdpi.com/1420-3049/24/6/1108
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