SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α

Hepatitis B virus (HBV) is a major public health threat and anti-HBV drugs are limited to nucleos(t)ide analogs (NAs) and pegylated interferon alpha (Peg-IFNα). Toward identifying an effective compound for HBV treatment is important to suppress and eradicate HBV. In this study, we explored the anti-...

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Main Authors: Hui Jiang, Sheng-Tao Cheng, Ji-Hua Ren, Fang Ren, Hai-Bo Yu, Qing Wang, Ai-Long Huang, Juan Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-10-01
Colecção:Frontiers in Pharmacology
Assuntos:
OSS_128167
SIRT6
hepatitis B virus
antiviral
core promoter
peroxisome proliferator-activated receptors α
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2019.01270/full
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