Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

Abstract Background Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer’s disease (AD) pathophysiologic continuum constituting what has been established as “AD signature”. To what extent MRI can detect amyloid-related cerebral changes from structural M...

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Autori principali: Paula M. Petrone, Adrià Casamitjana, Carles Falcon, Miquel Artigues, Grégory Operto, Raffaele Cacciaglia, José Luis Molinuevo, Verónica Vilaplana, Juan Domingo Gispert, for the Alzheimer’s Disease Neuroimaging Initiative
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-08-01
Serie:Alzheimer’s Research & Therapy
Soggetti:
Preclinical AD signature
Jacobian determinant
MRI
Machine learning
Longitudinal voxel-wise analysis
Accesso online:http://link.springer.com/article/10.1186/s13195-019-0526-8
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