Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer’s disease

Abstract Background Previous models of Alzheimer’s disease (AD) progression were primarily hypothetical or based on data originating from single cohort studies. However, cohort datasets are subject to specific inclusion and exclusion criteria that influence the signals observed in their collected da...

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Detalhes bibliográficos
Main Authors: Sepehr Golriz Khatami, Yasamin Salimi, Martin Hofmann-Apitius, Neil P. Oxtoby, Colin Birkenbihl, for the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Repository Without Borders Investigators
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Alzheimer’s Research & Therapy
Assuntos:
Alzheimer’s disease
Event-based models
Biomarker ordering
Disease progression
External validation
Meta-sequence
Acesso em linha:https://doi.org/10.1186/s13195-022-01001-y
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