Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells

Objective: Altered gene expression contributes to the development of type 2 diabetes (T2D); thus, the analysis of differentially expressed genes between diabetes-susceptible and diabetes-resistant mouse models is an important tool for the determination of candidate genes that participate in the path...

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Main Authors: Anneke Gässler, Charline Quiclet, Oliver Kluth, Pascal Gottmann, Kristin Schwerbel, Anett Helms, Mandy Stadion, Ilka Wilhelmi, Wenke Jonas, Meriem Ouni, Frank Mayer, Joachim Spranger, Annette Schürmann, Heike Vogel
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-11-01
Serier:Molecular Metabolism
Fag:
Gap junction
Connexins
Type 2 diabetes
Insulin secretion
Proliferation
Beta cell
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877820301162
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