Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study

Abstract Background Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation. Methods We used individual data from 285,495 participants in four population-based cohor...

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Main Authors: André F. S. Amaral, Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, Cosetta Minelli, Judith Garcia-Aymerich, Gabriela P. Peralta, Juha Auvinen, Ayoung Jeong, Emmanuel Schaffner, Anna Beckmeyer-Borowko, John W. Holloway, Marjo-Riitta Jarvelin, Nicole M. Probst-Hensch, Deborah L. Jarvis, for the ALEC consortium
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-06-01
Colecção:BMC Pulmonary Medicine
Assuntos:
Body mass index
Lung function
DNA methylation
Effect mediation
Mendelian randomisation
Acesso em linha:http://link.springer.com/article/10.1186/s12890-020-01212-9
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