Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore...

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Main Authors: Melissa Q. McDougall, Jaewoo Choi, Jan F. Stevens, Lisa Truong, Robert L. Tanguay, Maret G. Traber
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-08-01
Colecção:Redox Biology
Assuntos:
Brain
Development
Docosahexaenoic acid
H218O
Peroxidation
Vitamin E
Mass spectrometry
Phospholipids
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231716300064
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