Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Abstract The Kaplan–Meier (K–M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one cause of failure. In reality, failur...

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Main Authors: Prabin Dahal, Julie A. Simpson, Grant Dorsey, Philippe J. Guérin, Ric N. Price, Kasia Stepniewska
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2017-10-01
Series:Malaria Journal
Assuntos:
Plasmodium falciparum
Kaplan–Meier
Cumulative incidence function
Competing risks
Comparative studies
Acceso en liña:http://link.springer.com/article/10.1186/s12936-017-2074-7
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