Identification of Synergistic Drug Combinations to Target KRAS-Driven Chemoradioresistant Cancers Utilizing Tumoroid Models of Colorectal Adenocarcinoma and Recurrent Glioblastoma

Treatment resistance is observed in all advanced cancers. Colorectal cancer (CRC) presenting as colorectal adenocarcinoma (COAD) is the second leading cause of cancer deaths worldwide. Multimodality treatment includes surgery, chemotherapy, and targeted therapies with selective utilization of immuno...

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Bibliographic Details
Main Authors: Kshama Gupta, Jeremy C. Jones, Virginea De Araujo Farias, Yuri Mackeyev, Pankaj K. Singh, Alfredo Quiñones-Hinojosa, Sunil Krishnan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
KRAS
DDR1
BCR-ABL1
COAD
GBM
chemoradioresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.840241/full
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