Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids

Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential role of Up4A in development of hypertension. We...

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Detalhes bibliográficos
Main Authors: Zhichao Zhou, Inge M. Lankhuizen, Heleen M. van Beusekom, Caroline Cheng, Dirk J. Duncker, Daphne Merkus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-03-01
Colecção:Frontiers in Pharmacology
Assuntos:
Up4A
coronary
microcirculation
purinergic receptor
hypertension
prostanoid
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphar.2018.00255/full
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