Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer’s Disease Human Brains

Amyloid plaques and neurofibrillary tangles (NFTs) are hallmark lesions of Alzheimer’s disease (AD) related to β-amyloid (Aβ) deposition and intraneuronal phosphorylated tau (pTau) accumulation. Sortilin C-terminal fragments (shortened as “sorfra”) can deposit as senile plaque-like lesions within AD...

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Hlavní autoři: Tian Tu, Juan Jiang, Qi-Lei Zhang, Lily Wan, Ya-Nan Li, Aihua Pan, Jim Manavis, Xiao-Xin Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-05-01
Edice:Frontiers in Aging Neuroscience
Témata:
ABC score
brain banking
dementia
neurodegeneration
neuritic plaque
Vps10p
On-line přístup:https://www.frontiersin.org/article/10.3389/fnagi.2020.00093/full
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