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Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents

Abstract Non-steroidal anti-inflammatory drugs are among the most used drugs. They are competitive inhibitors of cyclooxygenase (COX). Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized in this work in order to identify which one was the most potent and which group wa...

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Détails bibliographiques
Auteurs principaux: Mohammed Hawash, Nidal Jaradat, Saba Hameedi, Ahmed Mousa
Format: Artigo
Langue:Inglês
Publié: BMC 2020-09-01
Collection:BMC Chemistry
Sujets:
COX
Accès en ligne:http://link.springer.com/article/10.1186/s13065-020-00706-1
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