Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion

Abstract Background Despite effectiveness of the combined antiretroviral therapy, HIV-1 persists in long-lived latently infected cells. Consequently, new therapeutic approaches aimed at eliminating this latent reservoir are currently being developed. A “shock and kill” strategy using latency-reversi...

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Autors principals: Alizé Proust, Corinne Barat, Mathieu Leboeuf, Jean Drouin, Michel J. Tremblay
Format: Artigo
Idioma:Inglês
Publicat: BMC 2017-12-01
Col·lecció:Journal of Neuroinflammation
Matèries:
CNS
Astrocytes
LRA
HIV-1 latency
Neuroinflammation
Excitotoxicity
Accés en línia:http://link.springer.com/article/10.1186/s12974-017-1019-y
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