A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs

G protein-coupled receptors (GPCRs) play a key role in many cellular signaling mechanisms, and must select among multiple coupling possibilities in a ligand-specific manner in order to carry out a myriad of functions in diverse cellular contexts. Much has been learned about the molecular mechanisms...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ambrose Plante, Derek M. Shore, Giulia Morra, George Khelashvili, Harel Weinstein
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2019-06-01
श्रृंखला:Molecules
विषय:
functional selectivity
biased ligands
molecular dynamics
deep neural networks
sensitivity analysis
pharmacological efficacy
ऑनलाइन पहुंच:https://www.mdpi.com/1420-3049/24/11/2097
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