Membrane Driven Spatial Organization of GPCRs

Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-det...

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Hlavní autoři: Mondal, Sayan, Johnston, Jennifer M., Wang, Hao, Khelashvili, George, Filizola, Marta, Weinstein, Harel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793225/
https://ncbi.nlm.nih.gov/pubmed/24105260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02909
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