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Ca (2+) -dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide

Cell penetration after recognition of the SARS-CoV-2 virus by the ACE2 receptor, and the fusion of its viral envelope membrane with cellular membranes, are the early steps of infectivity. A region of the Spike protein (S) of the virus, identified as the “fusion peptide” (FP), is liberated at its N-t...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Khelashvili, George, Plante, Ambrose, Doktorova, Milka, Weinstein, Harel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724664/
https://ncbi.nlm.nih.gov/pubmed/33299996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.03.410472
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