A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs

G protein-coupled receptors (GPCRs) play a key role in many cellular signaling mechanisms, and must select among multiple coupling possibilities in a ligand-specific manner in order to carry out a myriad of functions in diverse cellular contexts. Much has been learned about the molecular mechanisms...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ambrose Plante, Derek M. Shore, Giulia Morra, George Khelashvili, Harel Weinstein
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2019-06-01
Edice:Molecules
Témata:
functional selectivity
biased ligands
molecular dynamics
deep neural networks
sensitivity analysis
pharmacological efficacy
On-line přístup:https://www.mdpi.com/1420-3049/24/11/2097
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky